The Investigation of Gingival Crevicular Fluid Prosthoglandin E2 Level of the Type Ii Diabetes Mellitus Patients with Periodontitis

Diabetes mellitus (DM) is a risk factor for periodontal diseases and oral complications are frequently encountered in diabetic patients. In recent studies it was hypothesed that, the gingival crevicular fluid (GCF) prostoglandin E2 (PGE2) levels are higher in type I diabetic individuals than non diabetics. The aim of our study is to determine the GCF PGE2 levels of the individuals with type II dibetes mellitus and periodontitis. In addition it is aimed to investigate to correlation between the GCF PGE2 levels, the clinical parameters and the severity of the disease. 20 type II diabetes mellitus patient (group I), and 20 systhemic healthy ( group II), a total of 40 individual with periodontiis were examined. All individuals pocket depth (PD), plaque index (PI), gingival index (GI), and gingival bleeding index (GBI) scores were recorded to determine their clinical status. In addition to these, the volume of GCF was also determined from the same sampling side. The GCF PGE2 levels were determined by radioimmunoassay (RIA) method. The GCF PGE2 levels of I. and II. groups were determined sequentally as 61.88±28.71 and 13.30±4.953 pg/nm. The level of PGE2 level was determined significantly higher (p<0.001) in the group of diabetes mellitus patients than systhemic healthy group. Any correlation was not determined between the GCF PGE2 level and clinical parameters among both of the groups. By comparing all oral clinical parameters it was established that there was significiant differences between the groups (P<0.001). The PD and GCF amount of sampling site was also statistically different among the groups (p<0.05), but the difference of other parameter scores were not statistically important (p>0.05). The findings of this study confirms that diabetes mellitus is a risk factor for periodontal diseases and the correlation between GCF PGE2 level and the severity of the periodontal disease. Attracts attention for the GCF PGE2 level which could be used as a marker to determine the perodontal disease severity among type II diabetes mellitus patients. Introduction There are many studies about the correlation between diabetes and the forming of oral diseases. As there is no consensus the main opinion is; diabetes mellitus is arisk factor for periodontitis and the requent coincidation of oral complication in diabetes mellitus patients (1, 2, 3, 4-17). In recent epidemiological studies it was reported that diabetes increases the severity of severe